Paediatric Strategy Forum for medicinal product development in mitogen-activated protein kinase pathway inhibitors: ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration.
Pearson ADJ, Allen C, Fangusaro J, Hutter C, Witt O, Weiner S, Reaman G, Russo M, Bandopadhayay P, Ahsan S, Barone A, Barry E, de Rojas T, Fisher M, Fox E, Bender JG, Gore L, Hargrave D, Haekins D, Kreider B, Langseth AJ, Lesa G, Ligas F, Marotti M, Marshall LV, Nasri K, Norga K, Nysom K, Pappo A, Rossato G, Scobie N, Smith M, Stieglitz E, Weigel B, Weinstein A, Viana R, Karres D, Vassal G. Eur J Cancer. 2022 Oct 14;177:120-142. doi:10.1016/j.ejca.2022.09.036. Online ahead of print.
Molecular genetics of paediatric brain tumours and opportunities for precision medicine – a focus on infant brain tumors.
Rosenberg T & Bandopadhayay P. Curr Opin Neurol. 2022 Oct 5. doi: 10.1097/WCO.0000000000001110. Online ahead of print.
BH3 mimetics targeting BCL-XL impact the senescent compartment of pilocytic astrocytoma
Selt F, Sigaud R, Valinciute G, Sievers P, Zaman J, Alco C, Schmid S, Peterziel H, Tsai JW, Guiho R, Martinez-Barbera JP, Pusch S, Deng J, Zhai Y, van Tilburg CM, Schuman MU, Damaty AEL, Bandopadhayay P, Herold-Mende-C, von Deimling A, Pfister SM, Montero J, Capper D, Oehme I, Sahm F, Jones DTW, Witt O, Milde T. Neuro Oncol. 2022 Aug 17; noac199. doi: 10.1093/neuonc/noac199. Online ahead of print.
Single cell spatial analysis reveals the topology of immunomodulatory purinergic signaling in glioblastoma
Coy S, Wang S, Stopka SA, Lin JR, Yapp C, Ritch CC, Salhi L, Baker GJ, Rashid R, Baquer G, Regan M, Khadka P, Cole KA, Jwang J, Wen PY, Bandopadhayay P, Santi M, De Raedt T, Ligon KL, Agar NYR, Sorger PK, Touat M, Santagata S. Nat Commun Aug 16;13(1):4814. doi 10.1038/s41467-022-32420-w.
FOXR2 is an epigenetically regulated pan-cancer oncogene that activates ETS transcriptional circuits
Tsai JW, Cejas P, Wang DK, Patel S, Wu DW, Arounleut P, Wei Z, Zhou N, Syamala S, Dubois FPB, Crane A, Pelton K, Vogelzang J, Sousa C, Baguette A, Chen Z, Condurat AL, Dixon-Clarke S, Zhou KN, Lu SD, Gonzalez EM, Chacon MS, Digiacomo JJ, Kumbhani R, Novikov D, Hunter J, Tsoli M, Ziegler DS, Dirksen U, Jager N, Balasubramanian GP, Kramm CM, Nathrath M, Bieack S, Baker SJ, Zhang J, McFarland JM, Getz G, Aguet F Jabado N, Witt O, Pfister SM, Ligon KL, Hovestadt V, Kleinman CL, Long H, Jones DTW#, Bandopadhayay P#, Phoenix T#. Cancer Research 2022 July 8. doi:10.1158/0008-5472.CAN-22-0671. Online ahead of print.
Featured in the Broad Blog here.
Structural variants shape driver combinations and outcomes in pediatric high-grade glioma
Dubois FPB, Shapira O, Greenwald N, Zack T, Wala J, Tsai JW, Crane A, Baguette A, Hadjadj D, Harutyunyan AS, Kumar KH, Blattner-Johnson M, Vogelzang J, Sousa C, Kang KS, Sinai C, Wang DK, Khadka P, Lewis K, Nguyen L, Malkin H, Ho P, O’Rourke R, Zhang S, Gold R, Deng D, Serrano J, Snuderl M, Jones C, Wright KD, Chi SN, Grill J, Kleinman CL, Goumnerova LC, Jabado N, Jones DTW, Kieran MW, Ligon KL#, Beroukhim R#, Bandopadhayay P# Nat Cancer 2022 July 4. doi:10.1038/s43018-022-00403-z. Online ahead of print.
Featured in the DFCI Blog here.
Pediatric pineoblastoma: A pooled outcome study of North American and Australian therapeutic data
Hansford JR, Huang J, Endersby R, Dodgshun AJ, Li BK, Hwang E, Leary S, Gajjar A, Von Hoff K, Wells O, Wray A, Kotecha RS, Raleigh DR, Stoller S, Mueller S, Schild SE, Bandopadhayay P, Fouladi M, Bouffer E, Huang A, Onar-Thomas A, Gottardo N. Neurooncol Adv 2022 April 14; 4(1):vdac056. doi:10.1093.noajnl.vdac056. eCollection Jan-Dec 2022.
PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation
Khadka P*, Reitman Z*, Lu S, Buchan G, Gionet G, Dubois F, Carvalho DM, Shih J, Zhang S, Greenwald NF, Zack T, Shapira O, Pelton K, Hartley R, Bear H, Georgis Y, Jarmale S, Melanson R, Bonanno K, Schoolcraft K, Miller PG, Condurat AL, Gonzalez EM, Qian K, Morin E, Langhnoja J, Lupien LE, Rendo V, Digiacomo J, Wang D, Zhou K, Kumbhani R, Guerra Garcia ME, Sinai CE, Becker S, Schneider R, Vogelzang J, Krug K, Goodale A, Abid T, Kalani Z, Piccioni F, Beroukhim R, Persky NS, Root DE, Carcaboso AM, Ebert BL, Fuller C, Babur O, Kieran MW, Jone C, Keshishian H, Ligon KL, Carr SA, Phoenix TN#, Bandopadhayay P#. Nature Commun 2022 Feb 1; 13(1):604. doi: 10.1038/s41467-022-28198-8.
Featured on this Broad News Update.
Liquid biopsy detection of genomic alterations in pediatric brain tumors from cell-free DNA in peripheral blood, CSF and Urine.
Pages M, Rotem D, Gydush G, Reed S, Rhoades J, Ha G, Lo C, Fleharty M, Duran M, Jones R, Becker S, Haller M, Sinai CE, Goumnerova G, Golub TR, Love JC, Ligon KL, Wright K#, Adalsteinsson V#, Beroukhim R#, Bandopadhayay P#. Neuro Oncol 2022 Jan 4; noab99: doi: 10.1093/neuronc/noab299. Online ahead of print
Accuracy of central neuro-imaging review of DIPG compared with histopathology in the International DIPG Registry
The DIPG/DMG Registry. Neuro Oncol 2021 Oct 20; noab245: doi: 10.1093/neuronc/noab245. Online ahead of print
Molecular alterations in pediatric low-grade gliomas that led to death
Ahrendensen JT, Sinai C, Meredith DM, Malinowski S, Cooney TM, Bandopadhayay P, Ligon KL, Alexandrescu A. J Neuropathol Exp Neurol 2021 Nov 19; 80(11):1052-1059 doi: 10.1093/jnen/nlab097.
The challenges in treating embryonal tumors with multilayered rosettes (ETMR) and other infant brain tumors
Bandopadhayay, P and Chi, S. Neuro Oncol. 2022 Jan 5; 24(1):138-140 doi: 10.1093/neuroonc/noab206.
Characteristics of patients greater than 10 years of age with diffuse intrinsic pontine glioma: a report from the International DIPG/DMG Registry
The DIPG/DMG Registry. Neuro Oncol. 2022 Jan 5;24(1):141-152; doi: 10.1093/neuroonc/noab140.